Pemphigus vulgaris (PV) is a rare autoimmune blistering disorder affecting the skin and mucous membranes. It is characterized by the presence of intraepidermal blisters and acantholysis, resulting in erosions and crusting. PV can lead to severe complications and even death if left untreated. This clinical vignette on pemphigus vulgaris aims to assist residents in recognizing and diagnosing this challenging condition. Through this case, users will learn about the clinical features of PV, its differential diagnosis, and appropriate diagnostic and management strategies.

Paraneoplastic pemphigus (PNP) is a distinct variant of pemphigus, associated with underlying neoplasms, most commonly lymphoproliferative disorders. PNP presents with polymorphic skin lesions, including blisters, erosions, and lichenoid papules, often involving the mucous membranes as well. This clinical vignette will also introduce the concept of paraneoplastic pemphigus, highlighting its unique features, associations, and management considerations.

This vignette is an excellent resource for residents preparing for OSCE-style examinations and can also be used as a self-directed learning tool for healthcare professionals seeking to enhance their knowledge and skills in managing pemphigus vulgaris and understanding paraneoplastic pemphigus.

We invite you to explore the associated learning module and quizzes to reinforce your knowledge and test your understanding of this important topic.

1. Bolognia, J., Schaffer, J. V., & Cerroni, L. (2018). Dermatology (4th ed.). Philadelphia, PA: Elsevier
   
2. Photo Courtesy of DermNet NZ. “Pemphigus Vulgaris” https://dermnetnz.org/topics/pemphigus-vulgaris