Pemphigus foliaceus is an autoimmune blistering disorder affecting the skin, characterized by the presence of superficial blisters and crusts. It is caused by autoantibodies targeting desmoglein 1, a protein involved in cell adhesion within the upper layers of the epidermis. This clinical vignette on pemphigus foliaceus aims to assist residents in recognizing and diagnosing this challenging condition. Through this case, users will learn about the clinical features of pemphigus foliaceus, its differential diagnosis, and appropriate diagnostic and management strategies.

This vignette is an excellent resource for residents preparing for OSCE-style examinations and can also be used as a self-directed learning tool for healthcare professionals seeking to enhance their knowledge and skills in managing pemphigus foliaceus.

We invite you to explore the associated learning module and quizzes to reinforce your knowledge and test your understanding of this important topic.

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3. Leonardi C, Heffernan M, Gill Jennifer. “Rituximab and future biological therapies.” Comprehensive Dermatologic Drug Therapy (3rd Ed.) Stephen E. Wolverton. Toronto: Elsevier, 2013.
4. Werth VP et al. Diagnosis and management of pemphigus: Recommendations of an international panel of experts. J Am Acad Dermatol. 2020.