Palmoplantar keratoderma refers to a condition where the skin on the palms of the hands and soles of the feet becomes significantly thickened. It can be categorized based on inheritance patterns and clinical features. Diffuse keratoderma affects a large portion of the palms and soles, while focal keratoderma primarily affects areas under pressure. Punctate keratoderma leads to the formation of small bumps on the palms and soles. In some instances, the abnormal skin may extend beyond the palms and soles. Palmoplantar keratoderma can be either inherited or acquired, with hereditary cases resulting from gene abnormalities and acquired cases arising from changes in health or environment.

In this learning module, you will find a key point review on palmoplantar keratodermas focused on epidemiology, pathogenesis, clinical features, differential diagnosis and management. To test your knowledge, we refer you to the associated quiz (short answer format questions) and clinical vignettes simulating OSCE examinations.

Please select how you would like to proceed below:

1. Bolognia, J., Cerroni, L., & Schaffer, J. V. (2018). Dermatology.

2. Wolverton, S. E. (2013). Comprehensive dermatologic drug therapy. Edinburgh: Saunders.