Antimetabolites are drugs that interfere with the normal functioning of cells by disrupting various metabolic processes involved in DNA synthesis, repair, or cell division. In dermatology, these agents are used to treat a wide range of skin conditions, including psoriasis, eczema, and certain types of skin cancer. Examples of antimetabolites used in dermatology include hydroxyurea and Thioguanine.

While antimetabolites can be effective in treating certain skin conditions, they can also have serious side effects, including bone marrow suppression, liver or kidney damage, and increased risk of infection or cancer. As such, their use should be closely monitored to ensure safe and effective treatment.

This learning module will focus on the use of antimetabolites in dermatology, including their mechanisms of action, indications, contraindications, and potential adverse effects.

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1. Bolognia, J., Cerroni, L., & Schaffer, J. V. (2018). Dermatology. Philadelphia: Elsevier.

2. Wolverton, S. E. (2021). Comprehensive dermatologic drug therapy. Edinburgh: Saunders.