Ophthalmic herpes zoster, also known as herpes zoster ophthalmicus (HZO), is a reactivation of the varicella-zoster virus (VZV) in the ophthalmic division of the trigeminal nerve (V1). It can cause significant morbidity, including vision loss if left untreated. This clinical vignette on ophthalmic V1 herpes zoster aims to assist residents in recognizing and diagnosing this potentially sight-threatening condition. Through this case, users will learn about the clinical features of HZO, its differential diagnosis, and appropriate diagnostic and management strategies.

This vignette is an excellent resource for residents preparing for OSCE-style examinations and can also be used as a self-directed learning tool for healthcare professionals seeking to enhance their knowledge and skills in managing ophthalmic V1 herpes zoster.

We invite you to explore the associated learning module and quizzes to reinforce your knowledge and test your understanding of this important topic.

1. Photo courtesy of DermNetNZ https://dermnetnz.org/
2. Bolognia, J., Schaffer, J. V., & Cerroni, L. (2018). Dermatology (4th ed.). Philadelphia, PA: Elsevier
3. Bollea-Garlatti, M. L., Bollea-Garlatti, L. A., Vacas, A. S., Torre, A. C., Kowalczuk, A. M., Galimberti, R. L., & Ferreyro, B. L. (2017). Clinical characteristics and outcomes in a population with disseminated herpes zoster: A retrospective cohort study. Actas Dermo-Sifiliográficas (English Edition), 108(2), 145–152. https://doi.org/10.1016/j.adengl.2016.12.019