Neonatal lupus is a rare autoimmune condition in which autoantibodies from the mother cross the placenta, affecting the fetus. It typically presents with transient cutaneous lesions, but it can also cause potentially life-threatening cardiac abnormalities. This clinical vignette on neonatal lupus aims to assist residents in recognizing and diagnosing this rare condition. Through this case, users will learn about the clinical features of neonatal lupus, its differential diagnosis, and appropriate diagnostic and management strategies.

This vignette is an excellent resource for residents preparing for OSCE-style examinations and can also be used as a self-directed learning tool for healthcare professionals seeking to enhance their knowledge and skills in managing neonatal lupus.

We invite you to explore the associated learning module and quizzes to reinforce your knowledge and test your understanding of this important topic.

1. Bolognia, J., Schaffer, J. V., & Cerroni, L. (2018). Dermatology (4th ed.). Philadelphia, PA: Elsevier
2. Photo courtesy: Neonatal lupus erythematosus, DermNet NZ. https://dermnetnz.org/topics/neonatal-lupus-erythematosus