Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine skin cancer, often associated with the Merkel cell polyomavirus. It has a high potential for local recurrence and metastasis. This clinical vignette on Merkel cell carcinoma aims to guide residents in recognizing and diagnosing this challenging condition. Through this case, users will learn about the clinical features of MCC, its differential diagnosis, and appropriate diagnostic and management strategies.
This vignette is an excellent resource for residents preparing for OSCE-style examinations and can also be used as a self-directed learning tool for healthcare professionals seeking to enhance their knowledge and skills in managing Merkel cell carcinoma.
We invite you to explore the associated learning module and quizzes to reinforce your knowledge and test your understanding of this important topic.
Sources
- Bolognia J, Schaffer JV, Cerroni L. Dermatology. 4th edition ed: Philadelphia, Pa.: Elsevier; 2018 9th November 2017. 2880 p.
- Photo courtesy of DermNet NZ. Merkel Cell Carcinoma. DermNet NZ, https://dermnetnz.org/topics/merkel-cell-carcinoma/, Accessed March 27th 2023
- NCCN Guidelines Version 1.2021 Merkel Cell Carcinoma

Release Date: April 18th 2023
Last Updated: April 18th 2023
Time to complete: 30 minutes
Authors:
- Dr. Zeinah AlHalees, MD, University of British Columbia.
- Dr. Mathieu Powell, MD, McGill University.
- Dr. Elena Netchiporouk, MD, McGill University