Mastocytosis is a group of disorders characterized by the accumulation of mast cells in the skin and/or internal organs. It can present with various clinical manifestations, including skin lesions, flushing, and systemic symptoms. This clinical vignette on mastocytosis aims to guide residents in identifying and managing this heterogeneous condition. Through this case, users will learn about the clinical features of mastocytosis, its differential diagnosis, and appropriate diagnostic and management strategies.

This vignette is an excellent resource for residents preparing for OSCE-style examinations and can also be used as a self-directed learning tool for healthcare professionals seeking to enhance their knowledge and skills in managing mastocytosis.

We invite you to explore the associated learning module and quizzes to reinforce your knowledge and test your understanding of this important topic.

1. Chatterjee A, Ghosh J, Kapur R. Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder. Oncotarget. 2015 Jul 30;6(21):18250.
2. Alikhan, A., Hocker, T. and Chavan, R., 2017. Review Of Dermatology. Edinburgh [etc.]: Elsevier, pp.274-275.
3. Bolognia, J., Schaffer, J. V., & Cerroni, L. (2018). Dermatology (4th ed.). Philadelphia, PA: Elsevier.
4. Photo courtesy of DermNet NZ. https://dermnetnz.org/