Keratolytics are a group of agents that are used in dermatology for the treatment of various skin conditions that involve hyperkeratosis or thickened skin. These agents work by breaking down the keratin protein that forms the outermost layer of the skin, thereby promoting the shedding of dead skin cells and the subsequent smoothing of the skin surface.

Keratolytics can be used to treat a variety of conditions, such as psoriasis, corns, calluses, and acne. The different types of keratolytics include alpha-hydroxy acids, beta-hydroxy acids, urea, and salicylic acid. They are available in various formulations, including creams, lotions, gels, and solutions, and the concentration of the active ingredient may vary depending on the intended use and severity of the condition. Common adverse effects of keratolytics include skin irritation, dryness, and peeling.

In this learning module, you will find a comprehensive review of the different types of keratolytics used in dermatology, including their mechanisms of action, indications, contraindications, adverse effects, and drug interactions.

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1. Wolverton, S. E. (2021). Comprehensive dermatologic drug therapy. Edinburgh: Saunders.
2. Bolognia, J., Cerroni, L., & Schaffer, J. V. (2018). Dermatology. Philadelphia: Elsevier.