Intravenous immunoglobulin (IVIG) is a blood product that contains purified antibodies from the plasma of healthy donors. It is used to treat a variety of conditions related to the immune system, including primary and secondary immunodeficiencies, autoimmune diseases, and certain neurologic disorders.

In dermatology, IVIG is sometimes used as an off-label treatment for various autoimmune blistering diseases. IVIG works by modulating the immune system through a variety of mechanisms, including neutralization of pathogenic antibodies, inhibition of complement activation, and modulation of cytokine production.

IVIG is administered intravenously over several hours and may require multiple doses over several weeks or months. Side effects are generally mild and may include headache, nausea, and flu-like symptoms. More serious side effects are rare but may include allergic reactions, kidney problems, and blood clots.

While IVIG is not typically considered a first-line treatment for autoimmune blistering diseases, it can be a useful option for patients who have not responded to other therapies or who have severe disease.

In this module, you will learn about the various indications for IVIG therapy in dermatology, the mechanism of action of IVIG, dosing regimens, adverse effects, and drug interactions.

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2. Wolverton SE, Wu JJ. Comprehensive dermatologic drug therapy. 4th edition ed: Philadelphia, PA: Elsevier; 2021 19th March 2020. 1024 p.