Interferons are a group of naturally occurring proteins that play a role in regulating the immune system’s response to infections, tumors, and other diseases. In dermatology, interferon-alpha (IFN-α) is primarily used in the treatment of viral-induced skin conditions such as genital warts and herpes simplex.

IFN-α is typically administered via injection, either subcutaneously or intramuscularly. Treatment duration varies depending on the condition being treated, but may range from several weeks to several months. Common side effects of IFN-α therapy include flu-like symptoms, fatigue, and depression.

While IFN-α has shown efficacy in the treatment of viral-induced skin conditions, its use in dermatology is limited due to its significant side effects and the availability of alternative treatments such as antiviral medications. Additionally, the cost of IFN-α therapy can be high and requires close monitoring due to its potential for significant adverse effects.

In this module, you will learn about the different types of interferons used in dermatology, their mechanism of action, indications, contraindications, adverse effects, and drug interactions. You will also learn about the various routes of administration and dosing regimens for interferon therapy.

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1. Bolognia J, Schaffer JV, Cerroni L. Dermatology. 4th edition ed: Philadelphia, Pa.: Elsevier; 2018 9th November 2017. 2880 p.

2. Wolverton SE, Wu JJ. Comprehensive dermatologic drug therapy. 4th edition ed: Philadelphia, PA: Elsevier; 2021 19th March 2020. 1024 p.