Corticosteroids are a class of steroid hormones that are naturally produced by the adrenal cortex. Corticosteroids have several effects that contribute to their anti-inflammatory and immunosuppressive properties. They reduce the production and release of pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor-alpha, from immune cells. They also inhibit the activation and migration of immune cells, such as T-cells and macrophages, to sites of inflammation.

In dermatology, corticosteroids are used to treat a variety of inflammatory skin conditions, such as eczema, psoriasis, and allergic reactions. They are available in various formulations, including creams, ointments, gels, lotions, and solutions, with different potencies and modes of application. The choice of formulation and potency depends on the severity and location of the skin condition, as well as the age and medical history of the patient.

In this learning module, you will find a comprehensive review of corticosteroids, including their mechanism of action, indications, contraindications, adverse effects, and drug interactions.

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1. Bolognia J, Schaffer JV, Cerroni L. Dermatology. 4th edition ed: Philadelphia, Pa.: Elsevier; 2018 9th November 2017. 2880 p.

2. Wolverton SE, Wu JJ. Comprehensive dermatologic drug therapy. 4th edition ed: Philadelphia, PA: Elsevier; 2021 19th March 2020. 1024 p.