Azathioprine is an immunosuppressive medication that is commonly used in dermatology for the treatment of various skin conditions such as psoriasis, pemphigus vulgaris, and dermatomyositis. It works by inhibiting the production of certain immune cells, such as T and B cells, which are involved in the inflammatory process. Patients who are taking azathioprine require close monitoring for potential side effects, which can include bone marrow suppression, increased risk of infection, liver toxicity, and an increased risk of certain cancers.

This learning module provides a comprehensive review of azathioprine, its mechanism of action, indications, contraindications, adverse effects, and drug interactions.

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Sources

  1. Bolognia J, Schaffer JV, Cerroni L. Dermatology. 4th edition ed: Philadelphia, Pa.: Elsevier; 2018 9th November 2017. 2880 p.

  2. Wolverton SE, Wu JJ. Comprehensive dermatologic drug therapy. 4th edition ed: Philadelphia, PA: Elsevier; 2021 19th March 2020. 1024 p.
  • Release Date: March 20 2023

  • Last Updated: March 20 2023

  • Time to complete: 30 minutes

  • Authors:

    • Dr. Zeinah Alhalees, MD, University of British Columbia
    • Dr. Naif Aljahani, MD, Prince Sultan Military Medical City