Dipyridamole

  • Peak plasma after 75 min, half-life 10 hours
  • Metabolized by liver
  • Excreted in bile
  • Pregnancy Category B

  • Oral

  • In dermatology75 mg twice daily
  • 150-400 mg divided 3-4 times a day

  • Phosphodiesterase inhibitor
  • Inhibits platelet aggregation
  • Vasodilator

FDA approved

  • Adjunct with warfarin for prevention of thromboembolic event after valve replacement

Off-Label

  • * Used with aspirin for:
    • Livedoid vasculopathy
    • Degos disease
    • Necrobiosis lipoidica

  • Hypersensitivity
  • Recent myocardial infarction
  • Worsening angina

  • Gastric symptoms
  • Dizziness
  • Headache
  • Hypotension
  • Tachycardia
  • Worsening coronary heart disease
  • Bleeding
  • Elevated liver function tests and liver failure reported

* For further reading refer to a pharmacology source

The combination of aspirin with dipyridamole has the same rate of bleeding complications as low-dose aspirin alone