Menthol

  • Up to 16% (lotions, creams, gels, ointments)

  • Activates TRPM8 & TRPA1, providing cool sensation that relives itch
  • Possible central itch modulation via Aδ fiber +/- κ-opioid receptor activation

  • Useful in cases where itch is relieved by cold showers

  • Inflamed/eroded skin

  • Irritation
  • ACD (rare)

  • Inconsistent antipruritic effect in controlled studies