Return to course: Topical and Intralesional Chemotherapy used in Dermatology
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Vincristine
Description
Vinca alkaloids
Route
Intra-lesional
Dose
1-2mg vials
Mechanism of action
Binds to tubulin = microtubule inhibitor; cell arrest in metaphase
Indications
Off-label
Kaposi sarcoma
Contraindications
Pregnancy & lactation
Immuno-suppression
Vascular compromise
Side Effects
Erythema, burning
Mild-moderate pruritus
Ulceration (rare)
Interactions
* For further reading refer to a pharmacology source
Monitoring & Other
Inject 0,03-0,08 ml at concentration 1 μg/ml