Vinblastine

  • Vinca alkaloids

  • Intra-lesional

  • 10 mg vials

  • Binds to tubulin = microtubule inhibitor; cell arrest in metaphase

Off-label

  • Kaposi sarcoma
  • Keratoacanthoma

  • Pregnancy & lactation
  • Immuno-suppression
  • Vascular compromise

  • Pain, inflammation. blistering, post-inflammatory hyperpigmentation
  • Unclear if systemic absorption occurs

* For further reading refer to a pharmacology source

  • Inject in lesion to blanch entire lesion (0.03-1.0mL at concentration 0.5mg/ml)