Diffuse Palmoplantar Keratodermas (Isolated, Non-Syndromic)
Diffuse Palmoplantar Keratodermas with Ichthyosis
Diffuse Palmoplantar Keratodermas with Associated Features/Syndromic
Focal Palmoplantar Keraoderma without Associated Features
Focal Palmoplantar Keraoderma with Associated Features/Syndromic
Punctate Palmoplantar Keratoderma without Associated Features
Punctate Palmoplantar Keratoderma with Associated Features Syndromic
Acquired Keratodermas and Related Conditions
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Quiz
Vohwinkel Syndrome
- Gap junction protein beta-2 gene mutation
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- Bart–Pumphrey
- Keratitis– ichthyosis–deafness
- Encodes connexin 26 expression found in:
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- Palmoplantar epidermis
- Sweat gland
- Cochlea
- Autosomal dominant inheritance
- Abnormal connexin 26 expression leads to altered epithelial differentiation and sensorineural capacities
- Pitted, stippled, “honeycomb-like” diffuse palmoplantar keratoderma, “starfish” knuckle keratoses
- Pseudoainhum leads to digital autoamputation
- Nonprogressive high-tone sensorineural hearing loss
- Bart–Pumphrey syndrome
- Knuckle pads, leukonychia
- Honeycomb-like palmoplantar keratoderma
- High-tone sensorineural hearing loss
Pathology:
- Orthohyperkeratosis, papillomatosis
- Oral retinoids
- Surgical correction of scar-like bands
- Cochlear implantation for hearing loss