Diffuse Palmoplantar Keratodermas (Isolated, Non-Syndromic)
Diffuse Palmoplantar Keratodermas with Ichthyosis
Diffuse Palmoplantar Keratodermas with Associated Features/Syndromic
Focal Palmoplantar Keraoderma without Associated Features
Focal Palmoplantar Keraoderma with Associated Features/Syndromic
Punctate Palmoplantar Keratoderma without Associated Features
Punctate Palmoplantar Keratoderma with Associated Features Syndromic
Acquired Keratodermas and Related Conditions
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Punctate Palmoplantar Keratoderma, Buschke– Fischer–Brauer type
- Alpha and gamma adaptin-binding protein p34 and collagen type XIV α1 chain gene mutation
- Reported Collagen type XIV alpha 1 chain gene mutations
- Autosomal dominant inheritance
- Palmar crease involvement more common among patients of African lineage
- Altered intracellular transport of clathrin vesicles and processing of receptor tyrosine kinases
- Downstream increase in cell proliferation
- Small palmoplantar, potentially painful keratotic papules with central keratotic core, appearing in adolescence
- Unclear association with breast and colon carcinomas
Pathology:
- Epidermal depression, compact orthohyperkeratosis, hypogranulosis, parakeratosis, lengthened rete ridges
Differential:
- Verrucae
- Punctate porokeratosis
- Darier disease
- Cowden syndrome
- Arsenic / dioxin exposure
- Appropriate footwear
- Mechanical removal
- Oral retinoids
- Future considerations: receptor tyrosine kinase inhibitors
- Topical retinoids and keratolytics are not useful