Diffuse Palmoplantar Keratodermas (Isolated, Non-Syndromic)
Diffuse Palmoplantar Keratodermas with Ichthyosis
Diffuse Palmoplantar Keratodermas with Associated Features/Syndromic
Focal Palmoplantar Keraoderma without Associated Features
Focal Palmoplantar Keraoderma with Associated Features/Syndromic
Punctate Palmoplantar Keratoderma without Associated Features
Punctate Palmoplantar Keratoderma with Associated Features Syndromic
Acquired Keratodermas and Related Conditions
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Papillon–Lefèvre and Haim–Munk Syndromes
- Cathepsin gene mutation
- Autosomal recessive inheritance
- Abnormal cutaneous / immune cell serine protease activation
- Diffuse, transgredient palmoplantar keratoderma, erythema, pseudoainhum, hyperkeratotic psoriasiform plaques, childhood periodontitis with tooth loss
- Increased risk of pyogenic infection and hepatic abscess, acral melanoma, squamous cell carcinoma
- Haim–Munk syndrome
- Onychogryphosis, arachnodactyly, acro-osteolysis
- Unknown
- Oral retinoids decrease hyperkeratosis and risk of infection