Diffuse Palmoplantar Keratodermas (Isolated, Non-Syndromic)
Diffuse Palmoplantar Keratodermas with Ichthyosis
Diffuse Palmoplantar Keratodermas with Associated Features/Syndromic
Focal Palmoplantar Keraoderma without Associated Features
Focal Palmoplantar Keraoderma with Associated Features/Syndromic
Punctate Palmoplantar Keratoderma without Associated Features
Punctate Palmoplantar Keratoderma with Associated Features Syndromic
Acquired Keratodermas and Related Conditions
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Loricrin Keratoderma
- Loricrin (glycine-rich cornified envelope protein) gene mutation
- Abnormal loricrin transport leads to altered cornification
- Generalized desquamation or “collodion baby” at delivery with subsequent ichthyosis
- Diffuse non-epidermolytic palmoplantar keratoderma with “honeycomb pattern”
- pseudoainhum, knuckle pads, warty keratoses on extensors among children as in Vohwinkel syndrome without deafness
Pathology:
- Hyperkeratosis, parakeratosis, transitional cells, wide stratum granulosum, focal perinuclear vacuolization
- Nuclear immunoreactivity
Differential:
- Ichthyosis hystrix Curth-Macklin
- Isotretinoin