Malignancies associated with keratoderma:

• Bronchial carcinoma
  • Acquired diffuse palmoplantar keratoderma
• Breast, colon, kidney carcinoma
  • Filiform palmoplantar keratoderma
• Lung, stomach, genitourinary carcinoma
  • “Tripe palms”; palmar thickening, accentuated ridges, with acanthosis nigricans.
• Bazex syndrome (acrokeratosis paraneoplastica)
• Esophageal carcinoma
  • Howel–Evans syndrome

Keratoderma associated with malignancy:

• Huriez syndrome and palmoplantar keratoderma
  with sex reversal
  • Acral squamous cell carcinoma
• Mutilating palmoplantar keratoderma
  • Acral melanoma and the epithelioma cuniculatum squamous cell carcinoma variant

Keratoderma associated with gene mutations:

• SAM and SH3 domain-containing 1 gene mutation
  • Pigmentation defects, palmoplantar keratoderma, cutaneous squamous cell carcinoma

Keratoderma and malignancy associated with arsenic ingestion

• Arsenical keratoses (10-30 years post exposure)
  • Cutaneous squamous cell carcinoma
  • Lung and genitourinary carcinoma