Diffuse Palmoplantar Keratodermas (Isolated, Non-Syndromic)
Diffuse Palmoplantar Keratodermas with Ichthyosis
Diffuse Palmoplantar Keratodermas with Associated Features/Syndromic
Focal Palmoplantar Keraoderma without Associated Features
Focal Palmoplantar Keraoderma with Associated Features/Syndromic
Punctate Palmoplantar Keratoderma without Associated Features
Punctate Palmoplantar Keratoderma with Associated Features Syndromic
Acquired Keratodermas and Related Conditions
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Howel–Evans Syndrome
- Rhomboid 5 homolog 2 gene mutation
- Autosomal dominant inheritance
- Altered intramembrane protease function leading to increased epidermal growth factor receptor activity
- Epithelial hyperproliferation
- Aberrant wound healing
- Focal palmoplantar keratoderma at pressure sites (plantar more than palmar), keratosis pilaris, rough / xerotic skin, oral leukokeratosis around 5-15 years of age
- Increased risk for esophageal carcinoma by 50 years of age
- Unknown
- Unknown