Diffuse Palmoplantar Keratodermas (Isolated, Non-Syndromic)
Diffuse Palmoplantar Keratodermas with Ichthyosis
Diffuse Palmoplantar Keratodermas with Associated Features/Syndromic
Focal Palmoplantar Keraoderma without Associated Features
Focal Palmoplantar Keraoderma with Associated Features/Syndromic
Punctate Palmoplantar Keratoderma without Associated Features
Punctate Palmoplantar Keratoderma with Associated Features Syndromic
Acquired Keratodermas and Related Conditions
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Aquagenic Palmoplantar Keratoderma
- Onset in 2nd decade
- Females more than males
- Palmar aquagenic wrinkling in ~50% of cases of cystic fibrosis and ~10–25% of heterozygous carriers of cystic fibrosis transmembrane conductance regulator gene mutations
- Reports of autosomal dominant / recessive inheritance patterns
- Reported onset with use of cyclooxygenase-2 inhibitors
- Unknown
- Rapid onset of thickening and white / clear “pebbly” changes in palmar area after water contact
- Resolution when water exposure removed
- May have burning pain
Dermoscopy:
- Dilated acrosyringeal ostia
Pathology:
- Normal or dilated eccrine ostia, limited stratum corneum hyperkeratosis
Differential:
- Hereditary papulotranslucent acrokeratoderma
- Bothnia type of diffuse non-epidermolytic palmoplantar keratoderma
- Botulinum toxin injection
- Topical 20% aluminum chloride hexahydrate and urea cream