LE is a multi-organ systemic disease with frequent skin, joints, hematologic, pulmonary, renal & CNS involvement variably.

• 6 F : 1 M (systemic lupus erythematosus – SLE)
• 3 F : 1 M (cutaneous lupus erythematosus – CLE)

• Female sex (strongest risk factor)
• Age: females of childbearing years
• Ethnicity: African-American women (4-fold ↑ risk, younger age, ↑ mortality), prevalence in Caucasian/ Asian/Latin Americans (1/1000).

• All types of CLE may progress to SLE