Abrocitinib

Abrocitinib

  • Pregnancy category not classified yet.

  • From Pfizer

  • Oral

  • JAK1

Off-label

  • Atopic dermatitis (phase III trials underway as once-daily dose monotherapy); ongoing trials to compare dupilumab

Infections

  • Nasopharyngitis (most common)

Gastrointestinal

  • Nausea (most common), vomiting, abdominal pain

Cutaneous

  • Varicella zoster reactivation, eczema herpeticum, acne, folliculitis

Laboratory changes

  • Thrombocytopenia
  • Hyperlipidemia
  • Increased creatinine phosphokinase

* For further reading refer to a pharmacology source

Baseline

  • Complete blood count with differential
  • Electrolytes
  • Liver function tests
  • Lipid profile
  • Hepatitis B & C
  • Tuberculosis evaluation
  • Pregnancy test 

Notes

  • No changes in hemoglobin, lymphocyte or neutrophil counts reported in the atopic dermatitis trials