Common warts

Characteristic features: church spire papillomatosis heaped with ortho/parakeratosis, acanthosis, hypergranulosis +/- koilocytosis

Epidermodysplasia verruciformis (EV)

Orthokeratosis alternating with parakeratosis & acanthosis, cells with blue-gray, granular cytoplasm in the mid to upper epidermis

Mucosal warts
(always biopsy pigmented, erosive, bleeding, therapy-resistant genital lesions to rull-out malignancy)

Koilocytosis more prominent than common warts

Cervical intraepithelial neoplasia (CIN)

• Grade I → nuclear enlargement & hyperchromasia in lower epithelium
• Grade II → progressive atypia in all layers
• Grade III → epithelium totally replaced by atypical cells with lack of differentiation