Syndromes with extensive warts:

• WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis)

Autosomal dominant, primary immunodeficiency, mutations in gene encoding CXCR4 → impaired white blood cells trafficking/ homing → warts, hypo-gammaglobulinemia, bacterial infections, & myelokathexis

• WILD: Warts, cellular immunodeficiency, 1° lymphedema, multifocal anogenital dysplasia
• DOCK8 (autosomal recessive jobs)
• Severe combined immunodeficiency (SCID)
• GATA2 deficiency
• Idiopathic CD4 lymphopenia
• Acquired HIV (Human immunodeficiency virus)

Verrucous carcinomas Low-grade well-differentiated variant of squamous cell carcinoma associated with HPV (16, 18), locally invasive/ destructive but rarely metastasize

• Buschke Löwenstein

• Oral florid papillomatosis
• Epithelioma cuniculatum of sole
• Papillomatosis cutis carcinoides

Treatment: surgical, no radiation (risk of anaplastic transformation)

Other treatment: chemotherapy, interferon