Neonatal and infantile causes

  • Epidermolytic ichthyosis
  • Congenital ichthyosiform erythroderma
  • Netherton syndrome
  • Conradi-Hünermann-Happle syndrome
  • Rare ichthyoses: trichothiodystrophy, keratitis-ichthyosis-deafness (KID) syndrome, Sjögren-Larsson syndrome, neural lipid storage disease with ichthyosis

*Most common causes

  • Omenn syndrome
  • Other forms of severe combined immunodeficiency, agammaglobulinemia, complement deficiencies (C3, C5), immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
  • Wiskott-Aldrich syndrome

  • Staphylococcal scalded skin syndrome 
  • Neonatal “toxic-shock-like” exanthematous disease
  • Congenital cutaneous candidiasis

  • Atopic dermatitis
  • Seborrheic dermatitis
  • Psoriasis

  • Pityriasis rubra pilaris
  • Graft versus host disease
  • Diffuse cutaneous mastocytosis
  • Ankyloblepharon-ectodermal dysplasia-clefting syndrome
  • Nutritional dermatitis (including Kwashiorkor)