Therapeutic

Mucosal disease

• Topical antiseptics ±
• antihistamine ± anesthetic rinses 
• Oral antihistamines 
• If identifiable precipitating factor: specific therapy (e.g.: chronic suppressive antiviral therapy)
• Systemic corticosteroids (severe erythema multiforme with functional impairment)

Prophylaxis

• For HSV-associated: 
  • Oral acyclovir (10 mg/kg/day in divided doses)
  • Valacyclovir (500–1000 mg daily)
  • Famciclovir (250 mg twice daily)
• If resistant chronic EM: 
  • Azathioprine
  • Prednisone
  • Thalidomide
  • Dapsone 
  • Cyclosporine
  • Mycophenolate mofetil
  • Psoralen Ultraviolet A