Erythema multiforme (EM)
Stevens-Johnson Syndrome (SJS)/Toxic Epidermal Necrolysis (TEN)
Quiz
Pathology
Early lesions
- Apoptotic keratinocytes scattered in basal and suprabasal epidermis = hallmark
Late lesions
- Subepidermal vesicular (paci-immune)
- Epidermal necrosis/detachment
- Epidermis: CD8+ T cells and macrophagesÂ
- Dermis: CD4+ T cells