Clinical

  • Lesions appear in 24-72 hours
  • Pruritus and burning
  • Lasts 1-2 weeks without scarring, possible post-inflammatory pigment changes (hypopigmentation/hyperpigmentation)
  • Reactivation of HSV can lead to recurrence

Typical target skin lesions:

  • 1-3 cm 
  • Round, well-defined border with at least 3 distinct zones (bull’s eye), always papular:
  • Central circular zone with evidence of epidermal injury: bulla, crust or dusky appearance 
  • Pale pink edematous zone
  • Well-defined peripheral red ring

Atypical papular target lesions:

  • Round, edematous, palpable
  • Two zones/poorly defined border (in contrast to flat (macular) atypical targets in Stevens-Johnson syndrome/ Toxic epidermal necrolysis

Distribution:

  • Appear in crops with a symmetric pattern
  • Extremities (palms, soles, back of hands/feet, extensor surface of forearms/legs) and face 
  • Koebner +
  • Can involve the mucosa: bullae and vesicles cause painful erosions (buccal mucosa, lips, ocular, and genital mucosae)

Systemic manifestation:

  • Fever, asthenia, arthralgia (with joint swelling)
  • Atypical pneumonia-like
  • Rarely renal, hepatic and hematologic abnormalities