Clinical
- Lesions appear in 24-72 hours
- Pruritus and burning
- Lasts 1-2 weeks without scarring, possible post-inflammatory pigment changes (hypopigmentation/hyperpigmentation)
- Reactivation of HSV can lead to recurrence
Typical target skin lesions:
- 1-3 cm
- Round, well-defined border with at least 3 distinct zones (bull’s eye), always papular:
- Central circular zone with evidence of epidermal injury: bulla, crust or dusky appearance
- Pale pink edematous zone
- Well-defined peripheral red ring
Atypical papular target lesions:
- Round, edematous, palpable
- Two zones/poorly defined border (in contrast to flat (macular) atypical targets in Stevens-Johnson syndrome/ Toxic epidermal necrolysis
Distribution:
- Appear in crops with a symmetric pattern
- Extremities (palms, soles, back of hands/feet, extensor surface of forearms/legs) and face
- Koebner +
- Can involve the mucosa: bullae and vesicles cause painful erosions (buccal mucosa, lips, ocular, and genital mucosae)
Systemic manifestation:
- Fever, asthenia, arthralgia (with joint swelling)
- Atypical pneumonia-like
- Rarely renal, hepatic and hematologic abnormalities