Chaos & Clues for Pigmented Lesions

Evaluate how many patterns (based on geometric shapes) and colours there are.
  • Is there 1 pattern or > 1 pattern?
    • If yes, skip to step 2.
  • Is there 1 colour or > 1 color?
    • If yes, skip to step 2.
What the colors means…
  • Melanin:
    • Black: Melanin in the  stratum corneum)
    • Brown: Must be abrupt change (dark/light brown)
      • Dark brown: Melanin in the epidermis (dense)
      • Light brown: Melanin in the epidermis (delicate)
    • Gray: Melanin in the papillary dermis
    • Blue: Melanin in the reticular dermis
    • Orange: Combination of melanin and keratin, also serum crust
  • Keratin: Yellow, white (under stratum corneum)
  • Collagen: White (sclerosis), white could also mean absence of melanin
  • Blood: Red, or purple if poorly oxygenated

 

Chaos:
  • Chaos is defined as asymmetry of structure (i.e. pattern) and/or colour. Irregularity of shape does not matter.

Is there symmetry based on pattern or colour?

  • If 1 pattern only → Symmetry based on colour only
  • If 1 colour only → Symmetry based on patterns only
  • If 1 colour + 1 pattern only → Symmetrical by convention
If there is no Chaos (i.e. symmetrical)…
  • No intervention (move to next lesion on TBSE)
(A) There are 9 dermoscopic clues to malignancy:

(B) Can the clues you’ve identified be explained by Seborrhoeic Keratosis?
  • Clues to seborrheic keratosis:
  • Multiple orange clods
  • Multiple white clods
  • Thick curvy lines
  • Sharply demarcated border over the full periphery
  • Multiple grouped similar lesions
If Seb K does not explain the clues → Biopsy / Derm Referral.