Podophyllin

Podophyllin

  • Pregnancy Category X

Podophyllin is physician applied, in this formulation, the concentration of podophyllin is not standardized. Size treated must be limited to 10 cm2 and less than 0.5 mL per treatment

  • Extract from Mayapple plant: active ingredient is podophyllotoxin
  • Podophyllotoxin is an antimitotic agent that arrests cells in metaphase by reversibly binding tubulin

FDA

  • Genital warts

  • Inflammation, burning, erythema, erosions
  • Cases of death in context of systemic toxicity from overapplication / occlusion have been reported

  • Avoid in Pregnancy (mutagenic potential)

  • Podophyllin is not generally recommended due to toxicities
  • Important not to apply under occlusion or over apply as death has been reported (see Dose section on minimizing toxicity)
  • Not to be used on mucosal surfaces/open wounds/sores