Return to course: Antifungals
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Polyenes
Generic Name (class)
Nystatin
Pregnancy Category B
Formulations and Dosing
100000 USP units/g
Cream, ointment, powder
Oral suspension: 2-5 times a day
Slow Dissolving Pastille (lozenge): 4-5 times a day
Mechanism of Action
Fungistatic & fungicidal
Binds to membrane sterols of susceptible Candida species,
increases
membrane permeability leading to leakage of essential intracytoplasmic components
Spectrum of Activity
Candida albicans
& other
Candida spp.
Ineffective against Dermatophytes
Side Effects
Burning, pruritis, rash, eczema, pain on application
Rarely hypersensitivity reactions
Administration, Monitoring & Other
Insoluble in water, is not absorbed from intact skin, gastrointestinal tract or vagina