Allylamines & Benzylamines

Mechanism of Action (CLASS)

  • Inhibits squalene epoxidase leading to decreased ergosterol synthesis & accumulation of toxic squalene (fungicidal & fungistatic)
  • Highly lipophilic (penetration stratum corneum & hair follicles)

General Adverse Effects (CLASS)

  • Well tolerated
  • Can cause mild burning, itching, erythema, irritation & allergic contact dermatitis

Antifungal Potencies

  • Spectrum of Activity against Dermatophytes

    • Butenafine > Terbinafine > Ciclopirox = Naftifine > Azoles
  • Spectrum of Activity against Candida
    • Ciclopirox > Azoles > Butenafine > Naftifine > Terbinafine

Specific Medications

  • Pregnancy Category B
Medication Class
  • Allylamine
Formulation
  • 1-2% cream, gel
Spectrum of Activity & Other
  • Antifungal: dermatophytes, saprophytes
  • Anti-inflammatory: inhibition of neutrophil chemotaxis, & reactive oxygen species production; suppresses UVB-induced erythema

  • Pregnancy Category B
Medication Class
  • Allylamine
Formulation
  • Cream, spray
Spectrum of Activity & Other
  • 10-100x more potent than Naftifine
  • Antifungal: Dermatophytes, Candida, molds, dimorphic fungi
  • Antibacterial: Gram positive & Gram negative (including S. Aureus, Pseudomonas & C. acnes)

  • Pregnancy Category B
Medication Class
  • Benzylamine
Formulation
  • 1% cream
Spectrum of Activity & Other
  • Antifungal: dermatophytes, Candida, Aspergillus & dimorphic fungi
  • Anti-inflammatory: suppresses UVB-induced erythema