Norepinephrine-dopamine reuptake inhibitor

Bupropion

  • 3 formulations (immediate release, 12-hour sustained release, 24-hour extended release) *

  • Inhibits dopamine reuptake, modest effect on NE reuptake

  • Depression
  • Smoking cessation

  • *

  • As SSRIs+ ↓ Seizure threshold, & no sexual SE

  • *

  • As effective as SSRIs for depression with few sexual SE