Table of Contents

Sebaceous carcinoma

LEGEND

Sebaceous adenocarcinoma arising from Meibomian or Zeis glands located in the periocular region

  • Ocular epithelium with glands

  • Chalazion with granulomatous inflammatory reaction

Sebaceous carcinoma

LEGEND

  • Ocular epithelium with goblet conjunctival cells

Sebaceous carcinoma

Chalazion

Sebaceous carcinoma

LEGEND

  • Mostly dermal tumor, but attached to ulcerated epidermis with associated crusting

Sebaceous carcinoma

Multilobulated tumor with nests of cells containing lipid vacuoles, separated by dense fibrous stroma

Irregular and disorganized architecture

Sebaceous carcinoma

LEGEND

  • Sebaceous secretory material appearing as large eosinophilic (pink-staining) areas

Sebaceous carcinoma

LEGEND

  • Sebaceous secretory material presenting as large eosinophilic zones

Sebaceous carcinoma

LEGEND

  • Dense, fibrous, and vascular stroma at the periphery of sebaceous nests

Sebaceous carcinoma

LEGEND

Tumor lobules composed of a mixture of two cell types:

  • 1 – Basophilic germinative cells with large nuclei

  • 2 – Mature sebocytes with vacuolated cytoplasm

Sebaceous carcinoma

LEGEND

  • Cells with sebaceous differentiation containing large lipid vacuoles

Sebaceous carcinoma

LEGEND

  • High mitotic activity

Sebaceous carcinoma

LEGEND

  • Nuclear pleomorphism with altered, open, visible, and dispersed chromatin

Sebaceous carcinoma

Nuclear pleomorphism with alteration of chromatin becoming open, visible, and dispersed