Paget’s disease
LEGEND
Large cells, may be solitary or grouped in clusters
Upward migration within the epidermis, resembling a cluster of balloons released into the sky
Paler cells with abundant cytoplasm
Paget’s disease
LEGEND
Round, voluminous cells with pale cytoplasm
Nuclei show open and vacuolated chromatin
Paget’s disease
LEGEND
Mitotic activity is sparse
Paget’s disease
LEGEND
Large mucin-filled vacuole displaces the nucleus to the periphery (also known as signet-ring cell)
Extramammary Paget’s disease
LEGEND
Absence of dyskeratosis
Intraepidermal proliferation of large pale cells with abundant cytoplasm
Upward migration of these cells within the epidermis
Extramammary Paget’s disease
CK7 positive
