Table of Contents

Pretibial myxedema

LEGEND

  • Epidermal hyperplasia

  • Subepidermal “grenz zone” composed of normal collagen

  • Abundant mucin deposits replacing reticular dermal collagen

Pretibial myxedema

LEGEND

Perivascular and periannexal lymphocytic infiltrates with mast cells

  • Abundant mucin deposits

  • Collagen bundles separated by mucin become frayed and fragmented into fine strands

  • Large, star-shaped fibroblasts

Pretibial myxedema

Alcian blue and colloidal iron stains highlight the presence of mucin