Histiocyte

• A macrophage-type cell capable of performing phagocytosis
• Involved in granulomatous reactions
• Fusion of histiocytes leads to the formation of multinucleated giant cells
• Approximately 2 to 3 times larger than a lymphocyte
• Has a paler nucleus and cytoplasm compared to a lymphocyte
• The nucleus may be kidney-shaped (resembling a kidney)
• More basophilic (bluish) than a neutrophil or eosinophil
• The cytoplasm is often poorly defined, making it difficult to delineate its borders

Histiocytes

Neutrophils are smaller in size, with more eosinophilic cytoplasm and a multilobed nucleus.

Plasma cells have a darker nucleus, well-defined cytoplasm, and an eccentric nucleus.

Kidney-shaped nuclei (resembling the appearance of a kidney)

Some histiocytes become foamy, meaning they contain lipid vacuoles.