Spitzoid melanoma – low magnification
LEGEND
This is a melanoma that clinically and histologically resembles a Spitz nevus.
Numerous melanin granules in the dermis distributed asymmetrically
An asymmetrical, poorly defined lesion is observed at low magnification, with mild epidermal hyperplasia. The nests vary in size and shape and are not equidistant.
Dense band-like lymphocytic infiltrate beneath the melanocytic lesion
Spitzoid melanoma – high magnification
LEGEND
Vertically oriented nests composed of large, atypical spindle-shaped and/or epithelioid melanocytes
Frequent retraction artifact around nests
Absence of maturation, meaning that the melanocytes in the dermis are as large and atypical as those at the dermoepidermal junction
- Presence of Kamino bodies
Spitzoid melanoma – high magnification
LEGEND
Marked pleomorphism. Atypical spindle and epithelioid cells of highly variable sizes and shapes are seen.
Presence of mitoses in the dermis
