Nodular fasciitis – low magnification

Well-demarcated subcutaneous nodule with a myxoid stroma

Positive for vimentin, actin, and CD68

Nodular fasciitis – high magnification

LEGEND

  • Proliferation of broad spindle-shaped or stellate fibroblasts without atypia
  • Proliferation of small vessels with some lymphocytes and extravasated red blood cells (“tissue culture pattern”)

  • Spindle cells in the pale stroma may resemble a “feathery” appearance

    Frequent mitoses