Kaposiform Hemangioendothelioma
Mixed vascular tumor with capillary and lymphatic components, locally aggressive
Poorly circumscribed tumor
Nodules of spindle-shaped cells
Continuous spectrum with tufted angioma, which may represent a superficial variant
Kaposiform Hemangioendothelioma
LEGEND
Poorly circumscribed sheets of spindle-shaped endothelial cells infiltrating the reticular dermis and extending into the hypodermis
Adjacent fat lobules infiltrated by tumor cells
Hemosiderin granules resulting from erythrocyte extravasation
Kaposiform Hemangioendothelioma
LEGEND
Spindle-shaped cells associated with crescent-shaped vascular spaces resemble those seen in Kaposi sarcoma.
These two entities share histological similarities, hence the term kaposiform hemangioendothelioma.
Clear crescent-shaped clefts (also known as slit-like vascular lumina) are surrounded by infiltrative spindle-shaped endothelial cells.
Kaposiform Hemangioendothelioma
Spindle-shaped endothelial cells with hemosiderin granules – high magnification
