Infantile hemangioma
- Non-encapsulated tumor
- Multilobulated tumor
- Dense proliferation of capillary vessels composed of endothelial cells surrounded by pericytes
- Frequent mitoses in a hemangioma during the proliferative phase
Histological findings vary depending on the stage of the infantile hemangioma
Endothelial cells undergo apoptosis during the involution phase, leading to fibrosis
In the presented case, this is a mixed hemangioma (superficial and deep) in the proliferative phase.
Infantile hemangioma
Non-encapsulated tumor
Multilobulated tumor
Dense proliferation of capillary vessels composed of endothelial cells surrounded by pericytes
Infantile hemangioma
Non-encapsulated tumor
Multilobulated tumor
Dense proliferation of capillary vessels composed of endothelial cells surrounded by pericytes
Infantile hemangioma
LEGEND
Dense proliferation of capillary vessels composed of endothelial cells surrounded by pericytes
Ulceration
Infantile hemangioma
LEGEND
Multiple vascular lumina composed of proliferating endothelial cells
Infantile hemangioma
Multiple vascular lumina composed of proliferating endothelial cells
Infantile hemangioma – high magnification
Multiple vascular lumens composed of proliferative endothelial cells
Infantile hemangioma
LEGEND
Mixed infantile hemangioma, meaning localized in both the dermis and hypodermis (superficial and deep components)
Lobules of capillary vessels
Fat lobules
Infantile hemangioma
GLUT1 marker positivity
GLUT1 positivity allows differentiation of infantile hemangiomas from congenital hemangiomas
It should be noted that erythrocytes also stain with GLUT1; however, this staining is nonspecific. The staining of endothelial cells should be the focus.
