Angiosarcoma
Malignant, infiltrative, and poorly circumscribed vascular tumor
Tumor localized in the papillary and reticular dermis
Proliferation of endothelial cells forming irregular and angulated vascular slits that anastomose and dissect collagen fibers
Angiosarcoma
Malignant, infiltrative, and poorly circumscribed vascular tumor
Tumor localized in the papillary and reticular dermis
Proliferation of endothelial cells forming irregular and angulated vascular slits that anastomose and dissect collagen fibers
Angiosarcoma
Proliferation of endothelial cells forming irregular and angulated vascular slits that anastomose and dissect collagen fibers
Angiosarcoma
Vascular spaces of variable size that anastomose
Dissection of collagen fibers
Angiosarcoma
LEGEND
Multiple promontory signs, which consist of a proliferation of irregular vascular slits surrounding a pre-existing vessel in the dermis, creating the characteristic appearance of a vessel protruding into an abnormal vascular slit
Angiosarcoma
LEGEND
Promontory sign
Hemosiderin granules indicative of prior erythrocyte extravasation
Angiosarcoma
LEGEND
Marked nuclear pleomorphism (nuclei of varying sizes)
High mitotic activity
Angiosarcoma
LEGEND
Epithelioid cells (rounded cells with larger nuclei and abundant cytoplasm)
- Mitosis
