Scurvy

LEGEND

Vitamin C deficiency, which is a cofactor for the enzyme lysyl hydroxylase, an essential enzyme in collagen synthesis.

  • Atrophic epidermis

  • Loose and hypodense collagen, even fragmented in some areas

Scurvy

LEGEND

  • Disorganized hair and dilated follicular ostium, which clinically presents as corkscrew hair

  • Diffuse erythrocyte extravasation in both the papillary and reticular dermis, clinically manifesting as perifollicular petechiae

  • Loose and hypodense collagen

  • Perivascular and perifollicular lymphohistiocytic inflammatory infiltrate

Scurvy

Disorganized hair – high magnification

Scurvy

Disorganized hair – high magnification

Scurvy

Erythrocyte extravasation