Hailey-Hailey
LEGEND
- Massive suprabasal acantholysis
Marked acantholysis also present in the upper layers of the epidermis, resembling a dilapidated brick wall appearance
Hailey-Hailey – Massive acantholysis of the epidermal layers
LEGEND
An intraepidermal vesicle can be created by cytolysis, acantholysis, or spongiosis
In the case of spongiosis, intercellular bridges become visible
In the case of cytolysis (e.g., herpes virus infection), cytopathic changes can be observed
Perivascular lymphocytic infiltrate
In the case of acantholysis, intercellular bridges become disrupted, and keratinocytes take on a rounded shape
In Hailey-Hailey disease, acantholysis occurs throughout all layers of the epidermis, creating rounded keratinocytes that appear to float within the vesicle space
Hailey-Hailey
Acantholysis
Perivascular infiltrate
