Neurofibroma

LEGEND

Well-defined tumor

  • Non-encapsulated tumor localized in the dermis

Neurofibroma – low magnification

Well-defined, non-encapsulated nodule that can extend into the hypodermis

Neurofibroma

Composed of spindle cells in a pale pink fibrillary stroma, often referred to as “bubble-gum” pink

Spindle cells with random arrangement

Neurofibroma

LEGEND

  • Mast cells often present
  • Fibrillary stroma

Neurofibroma

Well-defined, non-encapsulated tumor

Neurofibroma

LEGEND

  • Spindle cells with random arrangement
  • Fibrillary stroma

  • Mast cells

Neurofibroma

Spindle cells in a pale pink fibrillary stroma

No particular organization

Neurofibroma

Well-defined tumor

Non-encapsulated tumor localized in the dermis

Stroma paler compared to the peripheral collagen

So-called “bubble-gum” stroma

Neurofibroma

LEGEND

Mainly composed of fibroblasts, Schwann cells, perineural cells, and mast cells (they may be present in variable quantities)

  • Spindle cells with wavy nuclei

Neurofibroma

LEGEND

Fibrillary stroma

  • Mast cells
  • Spindle cells with wavy nuclei

Neurofibroma – fibrillary stroma