Rheumatoid nodule
LEGEND
Necrobiosis is characterized by degeneration of connective tissue, particularly collagen, and the presence of fibrin.
Nodules are located in the deep dermis, near the hypodermis, and may even extend into the hypodermis.
There is an inflammatory infiltrate containing lymphocytes and histiocytes.
- Palisading histiocytes surround a zone of extensive necrobiosis
Rheumatoid nodule
LEGEND
Necrobiosis
Low cellularity with loss of fibroblast nuclei and intensely eosinophilic staining of degenerated collagen
Palisade surrounding the necrobiosis
Rheumatoid nodule
LEGEND
Nodule located in the deep dermis
Hypodermis and large-caliber blood vessels
Rheumatoid necrobiosis nodule
Degenerated collagen with marked eosinophilic staining
Loss of fibroblast nuclei
Rheumatoid nodule – overview
